Podophyllum hexandrum Offers Radioprotection by Modulating Free Radical Flux: Role of Aryl-Tetralin Lignans
نویسندگان
چکیده
منابع مشابه
Production of lignans in callus culture of Podophyllum hexandrum
Purpose: Podophyllum hexandrum Royle, a source of highly valued podophyllotoxin has been subjected to heavy collection from the wild. The ever-increasing demand of podophyllum is mainly due to two semi synthetic derivatives of podophyllotoxin that is etoposide and teniposide, which are used in the treatment of various types of cancer. The anti cancer lignan derivative podophyllotoxin in Podophy...
متن کاملIron chelation and related properties of Podophyllum hexandrum, a possible role in radioprotection.
Aqueous extract of Podophyllum species has been reported to render significant protection against radiation induced mortality, cytogenetic damage and cell death. In view of this, present study was undertaken to investigate its antioxidant properties. Chelation, oxidation and reduction of Fe2+ and Fe3+ were measured using chelating agents 2-2' bipiridyl and potassium thiocyanate respectively. Po...
متن کاملRadioprotective Nature of Podophyllum hexandrum (Himalayan Mayapple)
Human beings are at risk of the exposure of radiation or radioactive materials since the World War II. Nuclear proliferation and terrorist activities has further strengthened the threats of the exposure of ionizing radiation (IR) to military, civilian, and emergency responders. IR possesses sufficient energy to strip electrons from atoms or molecules and thereby create highly reactive ions. IR ...
متن کامل“podophyllum Hexandrum” – a Versatile Medicinal Plant
Podophyllum hexandrum a perennial herb, bearing the common name Himalayan Mayapple known as Aindri (a divine drug) in ancient times is native to the lower elevations in and surrounding the Himalaya. It has been reported to be used through the ages and in modern times as an intestinal purgative and emetic, salve for infected and necrotic wounds, and inhibitor of tumor growth. The rhizome of the ...
متن کاملFree radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection.
Aqueous extract of T. cordifolia inhibited Fenton (FeSO4) reaction and radiation mediated 2-deoxyribose degradation in a dose dependent fashion with an IC50 value of 700 microg/ml for both Fenton and radiation mediated 2-DR degradation. Similarly, it showed a moderate but dose dependent inhibition of chemically generated superoxide anion at 500 microg/ml concentration and above with an IC50 val...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2006
ISSN: 1741-427X,1741-4288
DOI: 10.1093/ecam/nel037